Polynucleotides are natural compounds derived from DNA and RNA fragments. Polynucleotides stimulate cellular regeneration by providing the skin with the necessary building blocks for collagen and elastin production.

Polynucleotide injections are administered through a series of microinjections into the skin, this minimally invasive approach reduces downtime and discomfort.

When injected into the skin polynucleotides signal two all-important changes to the way the skin behaves. First, it acts as a wound healing agent telling the skin to up regulate its repair mechanisms. This increase in cellular activity in the skin results in intense rejuvenation leaving the skin more supple with a marked reduction in the appearance of fine lines and wrinkles and other signs of aging.

It also has an anti-inflammatory effect, which means it reduces the negative effects of histamine on the skin which in turn allows the skin to focus on boosting cell renewal by increasing collagen production, improving elasticity and hydration.

Polynucleotides are commonly used to rejuvenate various areas of the face and body particularly in hard to treat areas such as the eyes. They work hard over a period of time to improve skin texture and health. We love them at SAS Aesthetics because they are rapidly becoming our treatment of choice for addressing traditionally difficult to treat like crepey skin and protect you against free radicals.

At a Glance

At a Glance

Downtime:

24-48 hours

Treatment duration:

30 minutes

Aftercare:

Avoid alcohol, smoking and hot showers for 6 hours. Avoid direct heat to the face for 7 days. No exercise for 24 hours.

Results can last:

Permanent - your skin is continuously ageing and repeat treatment is recommeneded to fight the signs of ageing every 6-12 months

Common side effects:

Minimal - mild redness, swelling and bruising can occur.

Treatment comfort:

Mild - topical anaesthetic is applied

Price:

From £400

Polynucleotides

Polynucleotides are natural compounds derived from DNA and RNA fragments. Polynucleotides stimulate cellular regeneration by providing the skin with the necessary building blocks for collagen and elastin production.

Polynucleotide injections are administered through a series of microinjections into the skin, this minimally invasive approach reduces downtime and discomfort.

When injected into the skin polynucleotides signal two all-important changes to the way the skin behaves. First, it acts as a wound healing agent telling the skin to up regulate its repair mechanisms. This increase in cellular activity in the skin results in intense rejuvenation leaving the skin more supple with a marked reduction in the appearance of fine lines and wrinkles and other signs of aging.

It also has an anti-inflammatory effect, which means it reduces the negative effects of histamine on the skin which in turn allows the skin to focus on boosting cell renewal by increasing collagen production, improving elasticity and hydration.

Polynucleotides are commonly used to rejuvenate various areas of the face and body particularly in hard to treat areas such as the eyes. They work hard over a period of time to improve skin texture and health. We love them at SAS Aesthetics because they are rapidly becoming our treatment of choice for addressing traditionally difficult to treat like crepey skin and protect you against free radicals.

Treatments — Face
Polynucleotide injections feature image headshot SAS aesthetics

At a Glance

At a Glance

Downtime:

24-48 hours

Treatment duration:

30 minutes

Aftercare:

Avoid alcohol, smoking and hot showers for 6 hours. Avoid direct heat to the face for 7 days. No exercise for 24 hours.

Results can last:

Permanent - your skin is continuously ageing and repeat treatment is recommeneded to fight the signs of ageing every 6-12 months

Common side effects:

Minimal - mild redness, swelling and bruising can occur.

Treatment comfort:

Mild - topical anaesthetic is applied

Price:

From £400

Before / After

Before & After

Frequently Asked Questions

How often should I repeat the treatment?

Initial treatment consists of 3 sessions spaced 2-4 weeks apart. For optimum results, repeat the treatment every 6-9 months.

What are the benefits?

Polynucleotides stimulate collagen and elastin production which improves skin texture, firmness, skin hydration, minimises the appearance of fine lines and wrinkles, promotes collagen and elastin production.

Is it painful?

We apply a topical anaesthetic to the skin prior to the procedure. This makes it a relatively pain-free treatment.

Are there any contra-indications?

Yes, the absolute contra-indications are pregnancy, breast feeding, fish allergy. Relative contra-indications are the use of blood thinning medications (please discuss this with your doctor during your consultation).

What is the difference between Fillers and Polynucleotides?

Dermal Fillers add volume to the face. For those who want to target the loss of collagen that results in skin sagging, fine lines and wrinkles, skin texture and health without having to add unnecessary volume. Polynucleotides is highly recommended.

What are polynucleotides made from?

Polynucleotides are biopolymers – stretchy molecules made from fragments of fish DNA extracted from salmon or trout which closely resemble human DNA.

As Seen In...

Patient Testimonials

Patient Testimonials
Patient Testimonials SAS Aesthetics

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Tox for wrinkles in the upper face is irreplaceable - period.

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DM to find out more ✨

#bingowings #armtreatments #bodyskintightening
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Sylfirm X uses dual-wave radiofrequency to treat everything from redness and melasma to skin laxity and texture.

Pulsed Wave (PW): This mode targets abnormal blood vessels and pigment without damaging surrounding tissue. It’s perfect for conditions like melasma, rosacea, and post-inflammatory hyperpigmentation (PIH). The short bursts of energy allow for controlled delivery, calming overactive vessels and pigment cells.

Continuous Wave (CW): This delivers a steady stream of RF energy deeper into the dermis, triggering collagen remodeling, skin tightening, and overall rejuvenation. It’s ideal for wrinkles, sagging skin, and large pores, helping to firm and lift over time.

The beauty of Sylfirm X is that we can customize treatments by switching between the two modes based on your specific skin concerns. One device, multiple layers of impact — from pigment control to collagen boost.

If you’re tired of chasing stubborn pigmentation or noticing your skin losing firmness, let’s build a personalized plan that actually works. Book a consultation and let’s get your skin back on track.

#SylfirmX #RFmicroneedling #SkinRejuvenation #MelasmaTreatment #CollagenBoost #rosaceatreatment
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Who said you can’t have lasers in the summer?! 

Refined lifted results and an uninterrupted lifestyle.

We know how busy everyone’s schedule is in the summer which is why we love to offer Sofwave for that instant lift without the downtime.

✔️ No downtime — resume your plans the same day
✔️ Safe for sunny destinations
✔️ Subtle, natural rejuvenation that builds over time

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Because true luxury is looking your best—without pressing pause.
#SofwaveSummer #EffortlessRefinement #LuxuryAesthetics #NoDowntimeNeeded
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Sylfirm X in Action at SAS Aesthetics ✨

This dual-energy treatment combines micro-needling with radio frequency to lift, tighten, and regenerate your skin from within with no downtime.

It targets:
✔️Redness & rosacea
✔️ Acne scars & pigmentation 
✔️ Fine lines & crepey skin 
✔️ Overall skin texture + tone

Performed by Dr Mahsa at SAS Aesthetics, Marylebone 

🧖🏻‍♀️ Book your treatment via link in bio or DM us!

#SylfirmX #SASAesthetics #SkinTightening #rosaceatreatment #collagen #microneedlingfacial
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Zaynn came in for a Carbon Laser Facial at SAS Aesthetics for a deep-cleansing, skin smoothing treatment that targets oil, texture and pigmentation in one go.

✅Unclogs pores
✅ Improves skin tone
✅ Reduces excess oil
✅ Instant glow, zero downtime 

🧖🏻‍♀️ DM us to book your skin detox!

#CarbonLaserFacial #LaserGlow #SkinRejuvenatiom #DeepCleanse #GlowingSkin #MensSkincare
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✨ Say hello to skin regeneration from the inside out!

Polynucleotide (PN) injections are the next-generation skin treatment making waves in regenerative aesthetics — and for good reason. Derived from purified DNA fragments (often from salmon or trout), PN works by activating your skin’s natural healing processes at a cellular level.

So what makes PN a game changer for aging and pigmentation?

✔️ Cellular Repair & Regeneration
PN stimulates fibroblast activity, accelerating collagen and elastin production — two essential proteins for firm, youthful skin. Think smoother texture, improved elasticity, and reduced fine lines.

✔️ Brightens Pigmentation & Uneven Tone
By encouraging cell turnover and improving skin health from within, PN helps to lighten hyperpigmentation, sun spots, and post-inflammatory marks — giving you a more even, radiant complexion.

✔️ Deep Hydration & Skin Barrier Support
PN enhances the skin’s ability to retain moisture, restoring a healthy, dewy glow. It also strengthens the skin barrier, making it more resilient against environmental damage and inflammation.

✔️ Anti-Inflammatory & Protective
Ideal for sensitive or compromised skin, PN reduces oxidative stress and calms inflammation, making it suitable even for those with rosacea or redness-prone skin.

✔️ Natural, Long-Term Results
Rather than masking issues, PN works with your body’s biology to restore and rebuild — meaning results are gradual, but deeply rooted and long-lasting.

—

Want expert guidance tailored to your skin?
Book a consultation with Dr. Mahsa Saleki, a trusted leader in advanced regenerative treatments. With her medical expertise and artistic approach, you’ll receive a personalised plan to restore youthful skin and even tone—safely and naturally.

📍DM us or click the link in bio to start your journey with Dr. Saleki today.

#SkinRejuvenation #PolynucleotideInjections #salmonsperm #salmonspermfacial
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✅ Deep Pore Cleansing – Removes dirt, oil, and dead skin trapped in pores.
✅ Reduces Acne & Blackheads – Targets active breakouts and minimizes future flare-ups.
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✅ Boosts Collagen – Promotes healing and improves overall skin health.

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